The development is an eight-storey, 19,695 square metre flexible-workspace scheme backed by a joint venture of developer Candour and the EPISO 5 fund managed by property investors Tristan Capital Partners.
Wates previously built both 2 and 3 Glass Wharf in Temple Quarter for developer Salmon Harvester Properties.
The latest building will include an events space, ground floor café with outdoor space, fitness facilities and landscaped terraces. BREEAM Outstanding and WELL Core Platinum certificates are targeted.
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Candour co-founder Toby Pentecost said: "Working in partnership with Tristan Capital Partners and supported by Apollo, we are committed to setting an example in sustainable development and delivering outstanding workspace for Bristol City Centre. We are already seeing significant interest from occupiers."
Debt financing for the scheme has been provided by an affiliate of Apollo Global Management.
Work is underway on site and is due for completion in 2023.
Bristol City Council is working with partners including Homes England and Network Rail to deliver the broader Temple Quarter project, a 100-hectare regeneration of land around Temple Meads station.
